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Mechanism of Action: Nitroglycerin nitroglycerin forms free radical nitric oxide (NO) which activates guanylate cyclase, resulting in an increase of guanosine 3’5′ monophosphate (cyclic GMP) in smooth muscle and other tissues .
These events lead to dephosphorylation of myosin light chains, which regulate the contractile state in smooth muscle, and result in nitroglycerin vasodilatation .
Pharmacodynamics: Consistent with the symptomatic relief of angina, digital plethysmography indicates that onset of the vasodilatory effect occurs approximately 1 to 3 minutes after sublingual nitroglycerin administration and nitroglycerin reaches a maximum by 5 minutes postdose .
Effects persist for at least 25 minutes following NITROSTAT Pharmacokinetics and Drug Metabolism Absorption: Nitroglycerin is rapidly absorbed following sublingual administration of nitroglycerin NITROSTAT tablets .
Mean peak nitroglycerin plasma concentrations occur at a nitroglycerin mean time of approximately 6 to 7 minutes postdose (Table 1) .
nitroglycerin Maximum plasma nitroglycerin concentrations (Cmax) and area under the plasma concentration-time curves (AUC) increase dose-proportionally following 0 . where to buy nitroglycerin tablets nitroglycerin 0.4 mg sublingual tablet how many nitroglycerin 6 mg NITROSTAT . 3 to nitroglycerin 2.5 angina and nitroglycerin nitroglycerin and nitric oxide nitroglycerin drug 0 .
The absolute bioavailability of nitroglycerin from NITROSTAT tablets is what do nitroglycerin pills do what are the side effects of nitroglycerin medical grade approximately 40% but tends to be variable due to factors influencing drug absorption, such as sublingual hydration and mucosal metabolism .

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