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Because of similar pharmacological properties, it is reasonable to expect similar risk with the concomitant use of other CNS depressant drugs with opioid palexia analgesics .
If the decision is made to prescribe a benzodiazepine or other CNS depressant concomitantly with an opioid analgesic, prescribe the lowest effective dosages and minimum palexia durations of concomitant use .
In patients already receiving an opioid analgesic, prescribe a lower initial dose of the benzodiazepine or other CNS depressant than indicated in palexia the absence of an opioid, and titrate based on clinical response .
If an opioid analgesic is initiated in a patient already taking a benzodiazepine palexia or other CNS depressant, prescribe a lower initial dose of the opioid analgesic, and titrate based on clinical response .
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