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It is a centrally acting opioid with two mechanisms of action, including agonism at the µ-opioid receptor palexia and noradrenaline reuptake inhibition .
[1] Tapentadol was marketed in two forms: immediate release, used mainly for acute pain management and sustained release tapentadol vs dihydrocodeine palexia tablets 50mg nucynta vs tramadol nucynta brain zaps nucynta iv (SR) for moderate-to-severe chronic pain .
Only tapentadol SR has been approved by the TGA palexia in Australia since December 2010 .
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[2] Starting Dose and Titration Opioid-prescribing guidelines should be palexia adhered to when considering tapentadol SR treatment for people with chronic pain .
Non-pharmacological and non-opioid measures for chronic pain should be considered and tapentadol 100 mg tablet nucynta er nucynta ssri tapentadol pillsbury nucynta full prescribing trialed before considering opioid analgesia .
[3] For opioid palexia naïve patients, start with 50 mg controlled release tablet twice daily (12 hourly); uptitrate dose by 50 mg twice daily every 3 days, according to response .
Maximum daily dose 500 For patients switching from a different opioid analgesic to tapentadol select tapentadol SR dose based on the mean daily dose of palexia their current medicine .
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