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They precipitate panadol and migrate towards cell membranes where they render cells fragile .
Haemolysis and restricted passage of erythrocytes through the microcirculation panadol and spleen may result in anaemia .
1 This is a panadol minor metabolite of paracetamol that is removed as N-acetyl conjugates . It has been suggested that the metabolite para-aminophenol, and not panadol NAPQI, is responsible for the methaemoglobinaemia seen in cats and dogs with paracetamol poisoning .
Cats have only one panadol packet panadol extra uses panadol overdose effects panadol 500 panadol and early pregnancy of the enzymes responsible for this reaction and dogs have none .
This means panadol that both species are less efficient at removing this toxic metabolite which is known to undergo reactions with oxyhaemoglobin .
Humans, panadol who frequently overdose with paracetamol and possess both enzymes, do not develop methaemoglobinaemia due to paracetamol toxicity .
• Acetylcysteine is a precursor of glutathione and is metabolised to form a substrate for panadol side effects long term panadol drug information panadol extra used for is panadol safe glutathione synthesis in red blood cells and • Acetylcysteine acts directly on the reactive metabolite NAPQI to form an acetylcysteine conjugate which can be excreted (although this reaction is slow) .
• Acetylcysteine is oxidised in panadol the liver to form sulphate thereby increasing the capacity of the sulphation pathway .

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