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No increased incidence of tumours pregabalin was observed in rats at exposures (plasma AUC) up to 25 times the expected Version: pfplyric10113 Supersedes: pfplyric10611 human exposure at the maximum recommended clinical dose of 600 mg/day .
In mice, no increased incidence of tumours was found at exposures similar to the expected maximum human exposure, but an increased incidence pregabalin of haemangiosarcoma was observed at exposures 6 to 33 times the expected maximum human exposure .
pregabalin The precise non-genotoxic mechanism of pregabalin-induced tumour formation is not fully characterised .
However, available data show that platelet changes associated with the formation of this tumour in mice are not seen in rats, monkeys or lyrica for fibromyalgia reviews pregabalina lyrical opera products lyrica otc lyrical dance humans .
Although long-term data in humans are limited, these findings in mice are thought not to pose a risk Effects on Ability lyrical dance competitions uk lyrical irish dance dress lyrica anxiety lyrica side effects teeth to Drive and Use Machines Pregabalin may cause dizziness and somnolence and therefore may have an influence on the ability to drive or use machines .
Patients are advised not to drive, operate complex machinery or engage in other potentially hazardous activities until lyrica sister lyrica dosage times lyrical dance footwear lyrical combo lyrica qatar lyrica class it is known whether this medication affects their ability to perform these activities .
INTERACTIONS WITH OTHER MEDICINES Since pregabalin is predominantly excreted unchanged in the urine, undergoes negligible metabolism in humans (<2% of a dose recovered in urine as metabolites), does not inhibit drug metabolism in vitro, and is not bound to plasma proteins, pregabalin is unlikely to produce, or be subject to, pregabalin pharmacokinetic interactions .

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