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In patients with moderate hepatic impairment, tapentadol should be used with caution and the dose should be initiated at 50 mg with tapentadol the interval between doses no less than 8 hours (maximum of 3 doses in 24 hours) .
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Subjects with severe hepatic impairment were not studied and it is appropriate that use of tapentadol in this population is tapentadol not recommended .
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Subjects with severe renal impairment were not tapentadol therapeutic category tapentadol nursing implications order palexia infarmed palexia studied in Phase II/III studies; therefore, the use in this subject population is not recommended .
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