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    Phentermine was shown in the 1970s to inhibit the metabolism of serotonin by monoamine oxidase (MAO), duromine cheaptickets adipex 37.5 tips side effects of adipex and lexapro adipex weight loss but never was labeled as an MAO inhibitor; hence, it was widely used in combination with fenfluramine, and continues to be used, in violation of their labels, with other serotonin uptake blockers .
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    adipex Phentermine inhibited serotoninmetabolizing (MAO-A) activity in all three tissues with Ki values of 85– 88 ␮M .
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    The adipex cardiac valvular lesions and primary pulmonary hypertension that have been reported to be associated with fenfluramine-phentermine use may have resulted from the intermittent concurrent blockage of both serotonin uptake and metabolism .
    phentermine; MAO-A; MAO-B; serotonin; amines; anorectics The anorexigen fenfluramine and its dextro-isomer dexfenfluramine have been implicated in the development adipex of echocardiographically defined cardiac valvular disease [1, 2] .

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