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FOLOTYN is supplied as a preservative-free, sterile, isotonic, non-pyrogenic probalan clear yellow aqueous parenteral solution contained in a single-use clear glass vial (Type I) for intravenous administration .
Each 1 mL of solution contains 20 mg of pralatrexate, sufficient sodium chloride to achieve an isotonic (280-300 mOsm) probalan use probalan drug class probalan dosage probalan probenecid (probalan) is used with solution, and sufficient sodium hydroxide, and hydrochloric acid if needed, to adjust and maintain the pH at 7 .
1 probalan cost probalan action probalan tabletas probalan side effects probalan action probalan Mechanism of Action Pralatrexate is a folate analog metabolic inhibitor that competitively inhibits dihydrofolate reductase . FOLOTYN is supplied as either 20 mg (1 mL) or 40 mg (2 mL) single-use vials at a concentration of 12 probalan CLINICAL PHARMACOLOGY 12 .
It is also a competitive inhibitor for polyglutamylation by the enzyme probalan 500 mg en colombia probalan spc probalan precautions probalan drug probalan dosage probalan folylpolyglutamyl synthetase .
3 Pharmacokinetics The pharmacokinetics of pralatrexate administered as a single agent at a dose of 30 mg/m2 administered as an intravenous push over 3-5 minutes once weekly for 6 weeks in 7-week cycles have been evaluated probalan tablet probalan diet probalan tablet come giocare bene midi probalan para que sirve come in 10 patients with PTCL . This inhibition probalan results in the depletion of thymidine and other biological molecules the synthesis of which depends on single carbon 12 .
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