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In the LIFE cozaar yan etki hyzaar wiki cozaar 100 mg 28 tablet etken maddesi hyzaar ne ilacıdır losartan study, Black patients with hypertension and left ventricular hypertrophy treated with atenolol were at lower risk of experiencing the primary composite endpoint compared with Black patients treated with COZAAR (both cotreated with hydrochlorothiazide in the majority of patients) .
The primary cozaar endpoint was the first occurrence of stroke, myocardial infarction or cardiovascular death, analyzed using an intention-to-treat (ITT) approach .
In the subgroup of Black patients (n=533, 6% cozaar of the LIFE study patients), there were 29 primary endpoints among 263 patients on atenolol (11%, 26 per 1000 patientyears) and 46 primary endpoints among 270 patients (17%, 42 per 1000 patient-years) on COZAAR .
This finding could not be explained on the basis of cozaar differences in the populations other than race or on any imbalances between treatment groups .
In addition, blood pressure reductions in both treatment cozaar groups were consistent between Black and non-Black patients .
Given the difficulty in interpreting subset differences in large trials, it cannot be known whether the observed difference is cozaar the result of chance .
However, the LIFE study provides no evidence that the benefits of COZAAR on reducing the risk of cozaar cardiovascular events in hypertensive patients with left ventricular hypertrophy apply to Black patients [see Clinical Studies (14 .
7 Renal Impairment cozaar Patients with renal insufficiency have elevated plasma concentrations of losartan and its active metabolite compared to subjects with normal renal function .

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