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When DESYREL is taken shortly after ingestion of food, there may be an increase in the amount of drug absorbed, a decrease in maximum concentration and a lengthening in the time to maximum desyrel depression reviews trazodone side effects anemia trazodone uses effects desyrel onset peak concentration .
Peak plasma desyrel levels occur approximately one hour after dosing when DESYREL is taken on an empty stomach or two hours after dosing when taken with food .
Elimination of DESYREL is biphasic, consisting of an initial phase (half-life 3–6 hours) followed by a slower phase (half-life 5–9 hours), and is unaffected by the desyrel presence or absence of food .
Since the clearance of DESYREL from the body is sufficiently variable, in some patients desyrel DESYREL may accumulate in the plasma .
For those patients who responded to DESYREL, one-third of the inpatients and one-half of the outpatients had a significant therapeutic response by the end of the desyrel first week of treatment .
Three-fourths of all responders demonstrated a significant therapeutic effect by the desyrel over the counter desyrel nhs trazodone side effects alopecia trazodone side effects end of the second week .
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