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The initial diazepam distribution phase is followed by a prolonged terminal elimination phase (half-life up to 48 hours) .
The terminal elimination half-life of the active metabolite N-desmethyldiazepam is up to diazepam 0 5 valium effects during pregnancy diazepam 10 mg cheap valium picture diazepam 5 mg webmd 100 hours .
Diazepam and its metabolites are excreted mainly in the urine, predominantly as their valium 2mg high diazepam 5 mg tablet nedir valium que es diazepam 5 mg para niños valium high werden glucuronide conjugates .
The clearance of diazepam is 20 to 30 diazepam mL/min in young adults .
Diazepam accumulates upon multiple dosing and there is some evidence that diazepam and tramadol high diazepam tolerance high diazepam used for pain valium dosage by weight the terminal elimination half-life is slightly prolonged .
Reference ID: 4029651 Pharmacokinetics in Special Populations In children 3 – 8 years old the mean diazepam im valium zum einschlafen valium high overdose diazepam natural substitute valium dosage half-life of diazepam has been reported to In full term infants, elimination half-lives around 30 hours have been reported, with a longer average half-life of 54 hours reported in premature infants of 28 – 34 weeks gestational age and 8 – 81 days post-partum .
In both premature and full term infants the active metabolite diazepam desmethyldiazepam shows evidence of continued accumulation compared to children .
Longer half-lives in infants may diazepam be due to incomplete maturation of metabolic pathways .
Elimination diazepam half-life increases by approximately 1 hour for each year of age beginning with a half-life of 20 hours at 20 years of age .
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