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The effect of eszopiclone on measures of depression has been evaluated in a number of clinical studies, including subjects with MDD (190-052), GAD lunesta reddit eszopiclone dose range lunesta and zzzquil lunesta and memory loss lunesta kidney (190-902), or women in the peri-menopausal transition (190-054) .
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The improvements in the antidepressant longest coma eszopiclone binding site lunesta heart rate eszopiclone zolpidem lunesta tolerance outcomes have been so significant that the Applicant is further evaluating the antidepressant effects in subjects with insomnia and MDD in an ongoing study in 11 countries throughout Europe (data not yet available) .
These benefits have been demonstrated to be eszopiclone separate from effects on sleep as the significant improvements remain, even when removing sleep items from the rating scales .
Further substantiating the clinical effects of the differences in receptor pharmacology, a study of the α1-selective zolpidem utilizing lunesta or ambien better lunesta and klonopin lunesta risks side effects lunesta and memory loss a design similar to that of the eszopiclone Study 190-052 showed no effect of zolpidem on the HAM-D total score compared to placebo (Figure 17) .

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