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Food imovane intake and weight gain were significantly affected and in a dose-related manner .
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Three of the fetuses were malformed, 1/109 live fetuses in the mid dose and 2/129 live fetuses in the high dose, exhibiting malformations of the urinary tract, exencephaly and forelimbs with zopiclone powder jamp-zopiclone 5mg imovane product monograph imovane classification zopiklon och clubfeet and malformations of the large heart vessels, respectively .
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In conclusion, zopiclone is not teratogenic in rabbits in doses up to imovane 125 mg/kg .
Perinatal and postnatal study This was a two generation study in which male and female offsprings (F1 generation) imovane of treated mothers were bred and the F2 generation also observed .
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