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Zidovudine – Experimental evidence demonstrated methadone side effects methadone clinics in ct methadone gynecomastia methadone qt prolongation that methadone increased the AUC of zidovudine which could result in toxic effects .
methadone Cytochrome P450 Inducers Methadone-maintained patients beginning treatment with CYP3A4 inducers should be monitored for evidence of withdrawal effects and methadone dose should be adjusted accordingly .
The methadone forms methadone kinetics methadone qtc monitoring methadone youtube methadone pills following drug interactions were reported following coadministration of methadone with inducers of cytochrome P450 Rifampin – In patients well-stabilized on methadone, concomitant administration of rifampin resulted in a marked reduction in serum methadone levels and a concurrent appearance of withdrawal symptoms .
Phenytoin – In a pharmacokinetic study with patients on methadone maintenance therapy, phenytoin administration (250 methadone medication methadone effects on fetus methadone for back pain methadone kinetics methadone mg b .
initially for 1 day followed by 300 mg QD for 3 to 4 days) resulted in an approximately 50% methadone reduction in methadone exposure and withdrawal symptoms occurred concurrently .
Upon discontinuation of phenytoin, the incidence of withdrawal NDA 17-116/S-021 symptoms decreased and methadone exposure increased to a level comparable to that prior methadone to phenytoin administration .
John’s Wort, Phenobarbital, Carbamazepine Administration of methadone along methadone with other CYP3A4 inducers may result in withdrawal symptoms .
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