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bradycardia, hypotension, pruritus, nasal Jaundice has been reported Life-Threatening or Leukopenia, seizures, and anaphylactic reactions have been reported Skeletal muscle robaxin effects side effects of robaxin 500mg robaxin and flexeril soma vs robaxin does robaxin relaxant, centrally acting Commonly Prescribed For (FDA approved in bold) Musculoskeletal conditions (adjunct to rest and physical therapy for relief of How the Drug Works Unclear but might be related to general CNS depression effect How Long until It Works Pain: 30 minutes or less What to Do about AEs Lower the dose or discontinue drug Best Augmenting Agents for AEs Most AEs cannot be improved by an augmenting Slowly titrate to most effective tolerated dose If It Doesn’t Work Increase to highest tolerated dose and consider alternative treatments Best Augmenting Combos for Partial Response or Treatment-Resistance Use other centrally acting muscle relaxants with caution due to potential additive CNS depressant Can combine with NSAIDs for acute pain ADVERSE EFFECTS (AEs) How Drug Causes AEs Most AEs are due to CNS depression Confusion, amnesia, dizziness, drowsiness, sedation, blurred vision, nystagmus, Usual Dosage Range 4–8 g/day in divided doses Tablets: 500 mg, 750 mg Injection: 100 mg/mL For acute muscle spasm: start 1500 mg 4 times daily (maximum 8 g/day) .

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