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Drug interactions

Dose reduction is recommended for patients with severe eszopiclone hepatic impairment .
LUNESTA should be used with caution in patients with hepatic impairment [see Dosage eszopiclone and Administration (2 .
Renal eszopiclone Impairment The pharmacokinetics of eszopiclone were studied in 24 patients with mild, moderate, or severe renal impairment .
eszopiclone AUC and Cmax were similar in the patients compared with demographically matched healthy control subjects .
No dose adjustment is necessary in patients with eszopiclone renal impairment, since less than 10% of the orally administered eszopiclone dose is excreted in the urine as parent drug .
Drug Interactions Eszopiclone is metabolized by CYP3A4 and CYP2E1 via demethylation eszopiclone and oxidation .
eszopiclone There were no pharmacokinetic or pharmacodynamic interactions between eszopiclone and paroxetine .
When eszopiclone was coadministered with olanzapine, no pharmacokinetic interaction was detected in lunesta dangers lunesta long term memory loss lunesta is not working eszopiclone dependence lunesta levels of eszopiclone or olanzapine, but a pharmacodynamic interaction was seen on a measure of psychomotor function .
Eszopiclone and lorazepam decreased each eszopiclone other’s Cmax by 22% .
2-fold increase in exposure eszopiclone to eszopiclone . Coadministration of eszopiclone 3 mg to subjects receiving ketoconazole, a potent inhibitor eszopiclone of CYP3A4, 400 mg daily for 5 days, resulted in a 2 .
Cmax and t1/2 were increased lunesta snort eszopiclone mylan does lunesta knock you out lunesta hives lunesta website generic 1 . eszopiclone 3-fold, respectively . 4-fold eszopiclone and 1 .

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