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The absorption curve lunesta kept me awake lunesta price in india lunesta bipolar lunesta blue pill dosage lunesta gaba of eszopiclone is shifted to the left by thirty minutes with respect to the racemate with a corresponding Tmax of 1 hour .
For drug elimination, the plasma concentrations of eszopiclone are approximately 20% lower at 8 hours post dose with eszopiclone than with racemate (on a ~ 1:2 mg The data presented consistently show via studies of comparable design, employing objective polysomnographic (PSG) methods that eszopiclone provides robust sleep onset effects, ~10 minutes faster compared to racemic zopiclone, lunesta usa lunesta high fat meal lunesta side effects vs ambien side effects lunesta leg cramps despite the lower recommended dose of 3 mg eszopiclone .
These effects are reproducible as demonstrated by the actigraphy data from the head-to-head eszopiclone study (ESZ111503) .
Thus as anticipated, the differences seen in the faster eszopiclone Tmax of eszopiclone translate into significantly faster sleep promoting effects for eszopiclone compared with racemic zopiclone .
With regard to differences in safety, a body of literature, including studies lunesta dosage lunesta side effects anxiety lunesta hypnotic lunesta side effects anxiety lunesta vs of comparable design demonstrates no significant next day impairment following eszopiclone, whereas racemic zopiclone is associated with significant next day impairment observed in studies evaluating driving, and cognitive and psychomotor outcomes .
The recently completed study (ESZ111503) that compared the residual effects of zopiclone eszopiclone to the single isomer eszopiclone further confirmed these observed effects, with eszopiclone differing significantly from zopiclone on an analysis of the primary psychomotor measure and secondary measures of memory impairment .

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