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(S)-N-desmethyl zopiclone, a metabolite of lunesta generic cost lunesta pi lunesta nausea next day lunesta side effects eyes lunesta generic vs eszopiclone, was positive in the Chinese hamster ovary cell and human lymphocyte chromosomal aberration assays .
It lunesta was negative in the bacterial Ames mutation assay, in an in vitro 32P-postlabeling DNA adduct assay, and in an in vivo mouse bone marrow chromosomal aberration and micronucleus assay .
Impairment eszopiclone and xanax lunesta vs ambien sleepwalking lunesta black box warning lunesta vs valium Of Fertility Eszopiclone was given by oral gavage to male rats at doses up to 45 mg/kg/day from 4 weeks premating through mating and to female rats at doses up to 180 mg/kg/day from 2 weeks premating through day 7 of pregnancy .
An additional study was lunesta issues lunesta liver eszopiclone street value lunesta side effects sweating eszopiclone performed in which only females were treated, up to 180 mg/kg/day .
Eszopiclone decreased fertility, probably because of effects in both males and females, with lunesta on drug screen lunesta youtube lunesta liver side effects lunesta makes me hungry lunesta no females becoming pregnant when both males and females were treated with the highest dose; the no-effect dose in both sexes was 5 mg/kg (16 times the MRHD on a mg/m2 basis) .
Other effects included increased pre-implantation lunesta loss (noeffect dose 25 mg/kg), abnormal estrus cycles (no-effect dose 25 mg/kg), and decreases in sperm number and motility and increases in morphologically abnormal sperm (no-effect dose 5 mg/kg) .

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