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In addition, modafinil has the potential to inhibit CYP2C19, modvigil suppress CYP2C9, and induce CYP3A4, CYP2B6, and CYP1A2 .
Because modafinil and acheter la poudre en vrac de modafinil acheter provigil egypte acheter modafinil brésil acheter du modafinil sulfone are reversible inhibitors of the drug-metabolizing enzyme CYP2C19, co-administration of modafinil with drugs such as diazepam, phenytoin and propranolol, which are largely eliminated via that pathway, may increase the circulating levels of PI + MG October 2010 those compounds .
, 7-10% of the Caucasian population; similar or lower in other acheter modafinil modalert uk modvigil pharmacie en ligne Jeanerette acheter modafinil asie acheter populations), the levels of CYP2D6 substrates such as tricyclic antidepressants and selective serotonin reuptake inhibitors, which have ancillary routes of elimination through CYP2C19, may be increased by co-administration of modafinil . In addition, in individuals deficient in modvigil the enzyme CYP2D6 (i .
Dose adjustments may be necessary for patients being treated with these and similar medications (See acheter modvigil Diners Club Louvain-la-Neuve acheter provigil amazon acheter modalert 200 inde PRECAUTIONS, Drug Interactions) .
An in vitro study demonstrated that armodafinil (one of the enantiomers of modafinil) modvigil is a substrate of Pglycoprotein .
Coadministration of modafinil with other CNS modvigil active drugs such as methylphenidate and dextroamphetamine did not significantly alter the pharmacokinetics of either drug .
Chronic administration of modafinil 400 mg was found to decrease the systemic exposure to two modvigil CYP3A4 substrates, ethinyl estradiol and triazolam, after oral administration suggesting that CYP3A4 had been induced .
Chronic administration of modafinil can modvigil increase the elimination of substrates of CYP3A4 .

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