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Chemistry and Pharmacology: Tramadol, named as 2-[(dimethylamino)methyl]-1-(3methoxyphenyl)cyclohexanol, in the Code of Federal Regulations, is a novel analgesic having tramadol both opioid agonist activity and monoamine reuptake inhibition that contribute to its analgesic efficacy .
Opioid activity is due to both the parent compound and tramadol withdrawal action plan tramadol hcl back pain tramadol 50mg for adults opiate withdrawal the more active Odesmethylated metabolite .
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Apart from analgesia, tramadol may produce a number of symptoms including dizziness, somnolence, nausea, and constipation similar to other tramadol opioids .
High doses of tramadol, often tramadol in combination with monoamine oxidase (MAO) inhibitors or selective serotonin reuptake inhibitors (SSRIs), have been associated with a serotonin syndrome consisting of convulsions, hyperthermia, muscle rigidity Tramadol is well absorbed orally .
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Seizures have occurred in patients taking recommended doses but are tramadol more likely at high doses associated with abuse of this medication .
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