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Trends in Psychopharmacology “multifunctional” with a trazodone different mixture of pharmacologic functions, depending upon how high a dose is given .
Trazodone’s most potent binding property is 5-HT2A trazodone antagonism .
9 In order for trazodone to act as a multifunctional SARI, trazodone side effects trittico bravo usato prezzi oleptro user reviews trazodone overdose reversal the effective antidepressant dose is pragmatically defined by trazodone’s ability to target the weaker of these two binding properties, in this case, SERT blockade . 6-11 Since both of these actions are considered necessary for antidepressant efficacy, trazodone’s multifunctional trazodone actions are sometimes categorized as “serotonin antagonist-reuptake inhibition” (SARI) (Figure 3A) . Its ability to trazodone overdose antidote trazodone side effects alzheimer’s trittico x camera da letto trazodone block SERTs is 100 fold less potent than its ability to block 5HT2A receptors (Figures 1 and 2) .
This means in practice that in order for trazodone to act as a SARI, trazodone overdose icd 10 molipaxin for fibromyalgia desyrel görsel trazodone cause insomnia oleptro it must be administered at a dose that is ten to fifty fold higher than that necessary for blocking 5-HT2A receptors (Figure 2) . 6-11 Other clinically relevant pharmacologic actions of trazodone are those at receptors where trazodone has moderate affinity, namely those with binding affinities between those it has for blocking 5-HT 2A receptors trazodone and SERT .

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