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ativan An increased risk of congenital malformations associated with the use of minor tranquilizers (chlordiazepoxide, diazepam and meprobamate) during the first trimester of pregnancy has been suggested in several studies .
In humans, blood levels obtained from umbilical cord blood indicate placental transfer of lorazepam and lorazepam ativan glucuronide .
Reproductive studies ativan in animals were performed in mice, rats, and two strains of rabbits .
Occasional anomalies (reduction of tarsals, tibia, metatarsals, malrotated limbs, gastroschisis, malformed skull, and microphthalmia) lorazepam side effects overdose lorazepam mouth dissolving tablets ativan side effects psychosis were seen in drug-treated rabbits without relationship to dosage .
Although all of these anomalies were not present in the concurrent control group, they have been ativan reported to occur randomly in historical controls .
At doses of 40 mg/kg orally or 4 ativan pills generic ativan cold turkey lorazepam side effects shaking lorazepam side effects ibs mg/kg intravenously and higher, there was evidence of fetal resorption and increased fetal loss in rabbits which was not seen at lower doses .
The possibility that a ativan woman of childbearing potential may be pregnant at the time of therapy should be There are insufficient data regarding obstetrical safety of parenteral lorazepam, including use in cesarean section .
Such use, therefore, is ativan not recommended .
Usage in Preterm Infants ativan and Neonates ATIVAN Injection contains benzyl alcohol .
Exposure to excessive amounts of benzyl alcohol has been associated with toxicity (hypotension, metabolic acidosis), particularly in neonates, and an increased incidence of ativan kernicterus, particularly in small preterm infants .
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