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Inducers of CYP3A4 The concomitant use of NORCO® and CYP3A4 inducers, such as rifampin, carbamazepine, and phenytoin, can decrease the plasma concentration of NORCO® [see CLINICAL PHARMACOLOGY], resulting in decreased efficacy or onset of a withdrawal syndrome in patients who have developed physical dependence to NORCO® [see After stopping a CYP3A4 inducer, as the effects of the inducer decline, the NORCO® plasma concentration will hydrocodone increase [see CLINICAL PHARMACOLOGY], which could increase or prolong both the therapeutic effects and adverse reactions, and may cause serious respiratory depression .
If concomitant hydrocodone rectal hydrocodone j code hydrocodone acetaminophen 5-325 overdose hydrocodone use is necessary, consider increasing the NORCO® dosage until stable drug effects are achieved .
Follow the patient for signs and symptoms hydrocodone acetaminophen 5-325 for fun hydrocodone pills hydrocodone quitting hydrocodone sleepy of opioid withdrawal .
If a CYP3A4 inducer is discontinued, consider NORCO® dosage reduction and follow for hydrocodone 5-325 breastfeeding hydrocodone pregnancy category hydrocodone en español hydrocodone 5 signs of respiratory depression .
Benzodiazepines and Other CNS Depressants Due to hydrocodone additive pharmacologic effect, the concomitant use of benzodiazepines and other CNS depressants, such as benzodiazepines and other sedative hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, and other opioids, including alcohol, can increase the risk of hypotension, respiratory depression, profound sedation, coma, and death .
Reserve concomitant prescribing of these drugs for hydrocodone use in patients for whom alternative treatment options are inadequate .
Limit dosages hydrocodone and durations to the minimum required .
Follow patients closely for signs of respiratory depression and sedation hydrocodone [see WARNINGS] .

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