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Derm: ACUTE GENERALIZED EXANTHEMATOUS PUSTULOSIS, STEVENS-JOHNSON SYNDROME, TOXIC acetaminophen EPIDERMAL NECROLYSIS, rash, urticaria .
Pharmacokinetics Absorption: Well acetaminophen absorbed following oral administration .
Rectal absorption acetaminophen is variable .
Intravenous administration results acetaminophen in complete bioavailability .
Distribution: acetaminophen dosage infants mg/kg acetaminophen and codeine phosphate acetaminophen dosage back Widely distributed .
Crosses the acetaminophen placenta; enters breast milk in low Metabolism and Excretion: 85– 95% metabolized by the liver (CYP2E1 enzyme system) .
Metabolites may be toxic in acetaminophen overdose situation .
Metabolites excreted by the Half-life: Neonates: acetaminophen 7 hr; Infants and Children: 3– 4 hr; Adults: 1– 3 hr .
Drug-Drug: Chronic high-dose acetaminophen (⬎2 acetaminophen g/day) mayqrisk of bleeding with warfarin (INR should not exceed 4) .
Hepatotoxicity is expired acetaminophen side effects acetaminophen vs ibuprofen for tooth pain acetaminophen for additive with other hepatotoxic substances, including alcohol .
Concurrent use of isoniazid, rifampin, rifabutin, phenytoin, barbiturates, and acetaminophen carbamazepine mayqthe risk of acetaminophen-induced liver damage (limit self-medication); these agents will alsop therapeutic effects of acetaminophen .
Concurrent use of NSAIDs mayqthe risk of adverse renal effects acetaminophen dosage for 8 year old acetaminophen liver enzymes acetaminophen salts acetaminophen (avoid chronic concurrent use) .
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