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It is widely accepted that propranolol and other non-selective beta- blockers are contraindicated propranolol in patients with asthma and Fatal adverse reactions due to propranolol had been described in adult patients asthma [20] .
However, there are hardly any case reports of wheezing in children propranolol while taking propranolol without a history or an underlying asthma .
Among the cases reported, all of them converting propranolol er to propranolol propranolol dose speech propranolol dose for high blood were adequately controlled with beta agonist and inhaled corticosteroids which suggests that © Under License of Creative Commons Attribution 3 . 0 License ARCHIVES OF MEDICINE propranolol may not be contraindicated if wheezing develops The mechanism by which propranolol may exacerbate wheezing is related to the propranolol receptors for bronchodilatation and bronchoconstriction .
Bronchodilatation is mediated through catecholamine stimulation of beta 2 receptors in propranolol the lung .
Non selective beta adrenergic blockers, such propranolol as propranolol, can cause bronchoconstriction [22] .
This propranolol process may lead to an exaggerated bronchoconstriction response to usually nontoxic stimuli such as a viral illness or aeroallergens [21] .
propranolol 5% to 32% [23] . Wheezing is very common in infancy, propranolol with reported prevalence of 28 .
The case of bronchial propranolol hyper reactivity can be attributed simply to underlying viral bronchiolitis because severity of bronchospasm in this illness is highly variable in infants [24] .
The cause of wheezing in our case (case 5) propranolol may have been multifactorial, and the authors cannot exclude the possibility of a viral induced wheeze .
During 2009-2015 one hundred infants with hemangiomas completed propranolol treatment with oral propranolol in our department .

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