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CYP1A2 Inhibitors Concomitant use of CLOZARIL and CYP1A2 inhibitors can increase plasma levels of clozapine, potentially resulting clozaril in adverse reactions .
, clozaril fluvoxamine, ciprofloxacin, or enoxacin) . Reduce the CLOZARIL dose to one third of the clozaril original dose when CLOZARIL is coadministered with strong CYP1A2 inhibitors (e .
The CLOZARIL dose should be increased to the original dose when coadministration of strong CYP1A2 inhibitors is clozaril brand name clozaril nursing clozaril controlled substance clozaril guidelines clozaril pdf discontinued [see DOSAGE AND ADMINISTRATION, CLINICAL PHARMACOLOGY] .
Moderate clozaril or weak CYP1A2 inhibitors include oral contraceptives and caffeine .
Monitor clozaril patients closely when CLOZARIL is coadministered with these inhibitors .
Consider reducing the CLOZARIL dosage if clozaril initiation clozaril vs generic clozaril contraindications clozaril medication clozaril necessary [see DOSAGE AND ADMINISTRATION] .
clozaril CYP2D6 And CYP3A4 Inhibitors Concomitant treatment with CLOZARIL and CYP2D6 or CYP3A4 inhibitors (e . , cimetidine, escitalopram, erythromycin, paroxetine, purchase clozaril with paypal clozaril uses clozapine ocd clozaril weight gain clozaril erowid bupropion, fluoxetine, quinidine, duloxetine, terbinafine, or sertraline) can increase clozapine levels and lead to adverse reactions [see CLINICAL PHARMACOLOGY] .
Use caution and clozaril monitor patients closely when using such inhibitors .
Consider clozaril reducing the CLOZARIL dose [see DOSAGE AND ADMINISTRATION] .

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