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A number of these findings are similar lunesta generic picture lunesta package insert eszopiclone in elderly lunesta liver lunesta drug to those observed in mice .
Repeat dose toxicity (with toxicokinetics) Based on the findings observed lunesta nausea lunesta vs seroquel lunesta liver damage eszopiclone vs zolpidem eszopiclone long in the repeat dose toxicity studies and the carcinogenicity studies the NOAELS and indicated safety margins based on systemic exposure are outlined in the Table below .
(S)-Zopiclone eszopiclone and (S)-DMZ (ng . h/ml) 35,152 Genotoxic potential of eszopiclone was assessed in several eszopiclone studies: in vitro bacterial and mammalian mutation assays, in vitro chromosome aberration assays, in vivo mouse micronucleus test, and in vivo unscheduled DNA synthesis in rat hepatocytes .
The eszopiclone overall results are exposed in the Table below .
From the test battery adverse side effects of lunesta lunesta discount lunesta vs ambien dosage lunesta hair loss lunesta performed, positive clastogenic activity was observed at high concentrations of eszopiclone for nonactivated (-S9) condition in one of two CHO chromosomal aberration studies .
The concentrations at which positive clastogenic effects were seen (1200 and 1400 μg) were higher than the eszopiclone cytotoxic ones (>240 μg/L) .
Other in vitro and in vivo assays performed were negative, including the in vitro mouse lymphoma, in vivo mouse bone marrow micronucleus, and unscheduled DNA eszopiclone synthesis in rat hepatocytes studies .
Also the in vivo 6-month oncogenicity study in p53+/- transgenic mice, lunesta vs trazodone lunesta nz side effects from lunesta lunesta side effects sweating eszopiclone a model recognized for its sensitivity to mutagenic carcinogens was negative (no induced tumours where observed) .

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