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PROPRANOLOL safety information

Isoproterenol and aminophylline propranolol may be used for bronchospasm .
PHARMACOLOGICAL PROPERTIES Pharmacodynamic properties Pharmacotherapeutic group: Beta-Blocking agent, non-selective, ATC code: C07AA05 Mechanism of action Potential mechanisms of action of propranolol in proliferating infantile haemangioma described in the literature could include various mechanisms all in close relationship: a local haemodynamic effect (vasoconstriction which is a classical consequence of betaadrenergic blockade and a decrease of infantile haemangioma lesion perfusion); an antiangiogenic effect (decrease of vascular endothelial cells proliferation, reduction of the neovascularization and formation of vascular tubules, reduction of the secretion of Matrix Metalloproteinase 9); an apoptosis-triggering effect on capillary endothelial cells; a reduction of both VEGF and bFGF signalling pathways and subsequent angiogenesis / Pharmacodynamic effects Propranolol is a beta-blocker that is characterised by three pharmacological properties: the absence of cardioselective beta-1 propranolol beta-blocking activity, an antiarrhythmic effect, lack of partial agonist activity (or intrinsic sympathomimetic activity) .
Clinical efficacy and safety in the paediatric population propranolol making anxiety worse propranolol extended release propranolol hydrochloride long acting The efficacy of propranolol in infants (aged 5 weeks to 5 months at treatment initiation) with proliferating infantile haemangioma requiring systemic therapy has been demonstrated in a pivotal randomised, controlled, multicentre, multidose, adaptive phase II/III study aimed to compare four regimens of propranolol (1 or 3 mg/kg/day for 3 or 6 months) to placebo (double blind) .
Treatment was administered to 456 subjects (401 Propranolol at a dose of 1 or 3 propranolol mg/kg/day for 3 or 6 months; 55 Placebo), including a titration phase over 3 weeks .

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