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Dosage of PURINETHOL

Clinical studies of PURINETHOL did not include sufficient purinethol numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects .
Other reported clinical purinethol experience has not identified differences in responses between the elderly and younger patients .
In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, purinethol and of concomitant disease or other drug therapy .
ADVERSE REACTIONS The principal and potentially serious toxic effects of PURINETHOL are bone purinethol marrow toxicity and hepatotoxicity (see WARNINGS and PRECAUTIONS) .
The most frequent adverse reaction to PURINETHOL purinethol is myelosuppression .
The induction of complete remission of acute lymphatic purinethol leukemia frequently is associated with marrow hypoplasia .
Patients without TPMT enzyme activity (homozygous-deficient) are particularly susceptible to hematologic toxicity, and some patients with low or intermediate TPMT enzyme activity are more susceptible to hematologic toxicity than patients with normal TPMT activity (see Reference ID: 2953022 WARNINGS, Bone Marrow Toxicity), although the latter can purinethol also experience severe toxicity .
purinethol Maintenance of remission generally involves multiple-drug regimens whose component agents cause myelosuppression .
Anemia, leukopenia, and thrombocytopenia purinethol tablet 50 mg purinethol haaruitval purinethol tablet 50 mg purinethol gewichtstoename are frequently observed .
Dosages and also schedules purinethol are adjusted to prevent life-threatening cytopenias .

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