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Description of MODVIGIL

The 400 mg dose in study 303 did not lead modvigil to higher MWT differences or improved ESS score than the 200 mg dose .
The efficacy in the long term has also not been modvigil demonstrated, as the existing long term data is uncontrolled and only subjective parameters were measured .
Shift Work modvigil Sleep Disorder In study 305 (a phase 3 randomised, double-blind, placebo-controlled study), a modest but statistically significant improvement was observed in the MSLT score .
However, the clinical relevance of this increase is questionable as, at the end of the modvigil study, the patients would still be characterised as severely ill (severe illness according to ICSD-1 is usually associated to MSLT scores below 5) .
This is further illustrated by the fact that patients at the end of the trial were sufficiently sleepy to meet the entrance criteria for the modvigil study (MSLT<6 minutes) .
While a significant improvement was seen in CGI-C and PVT scores for modafinil treated subjects, these are subjective measures and their validity for use in this specific type of sleep disorder modvigil is unclear .
While improvement was reported on modvigil the number of accidents or near accidents during the commute, no account was taken for the type or duration of the commute and no baseline values were collected .
Therefore this information is of prescription en ligne pour modvigil acheter modafinil pendant la nuit acheter modafinil sun pharma limited value .
modvigil The efficacy in the long term has also not been demonstrated .
Existing long term data are not controlled, are based on a subjective parameter and have failed to demonstrate a significant effect of Following consultation with the SAG, the CHMP concluded that the effects on both subjective and objective measures did modvigil not provide clear evidence of overall beneficial effect .

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