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*N-acetylation of compounds involves two enzymes, N-acetyltransferase 1 and Nacetyltransferase 2 (NAT1 panadol and NAT2) .
Cats have only NAT1 and dogs have no NAT enzymes effective and efficient detoxification pathway despite the fact that panadol cats have low glutathione concentrations .
At higher paracetamol doses, the glucuronidation and sulphation routes are saturated and the oxidation pathway panadol increases in activity .
This results in increased panadol production of NAPQI, causing glutathione depletion in the liver .
NAPQI then binds panadol with cellular molecules and proteins causing cell death in the liver .
qxp_FF panadol Layout1 06/10/2015 09:11 Page 3 Keeping cats safe induce methaemoglobin formation, Heinz body formation and denaturation of erythrocyte membranes . Oxidising metabolites Alternative metabolic pathways also allow accumulation of oxidising metabolites panadol that may paracematol-bates .
In the presence of glutathione, methaemoglobin will be panadol reduced to haemoglobin .
However, panadol as glutathione becomes depleted insufficient quantities will be available for this reduction reaction .
Methaemoglobin concentrations panadol in blood rise (it is typically measured as a percentage of haemoglobin) and tissue hypoxia occurs .
Heinz bodies are denatured panadol chains of haemoglobin with oxidised sulphydryl groups .
They precipitate and migrate towards cell membranes where panadol and children panadol products panadol extra vs panadol panadol actifast price panadol recall they render cells fragile .
Haemolysis and restricted passage panadol of erythrocytes through the microcirculation and spleen may result in anaemia .

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