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The procoralan effect of a dose increase on the heart rate should be carefully monitored .
5 procoralan mg twice daily . procoralan The maintenance dose of ivabradine should not exceed 7 .
If, during treatment, heart rate decreases below 50 beats procoralan per minute (bpm) at rest or the patient experiences symptoms related to bradycardia, the dose must be titrated downward including the lowest dose of 2 . 5 mg procoralan twice daily .
After dose reduction, heart procoralan rate should be monitored .
Treatment must be discontinued if heart rate remains below 50 bpm or symptoms of bradycardia persist despite Further information on the safety concern The procoralan above recommendations are made following the evaluation of the results of the SIGNIFY study (Fox et al, NEJM 2014) .
procoralan This randomised placebo-controlled study was performed in 19,102 coronary artery disease patients without clinical heart failure .
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