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Omeprazole, given in doses of 40 mg to healthy subjects in a cross-over study, increased Cmax and AUC for cilostazol by 18% and what are nexium pills for nexium tablets what are they used for does nexium treat ulcers nexium side 26% respectively, and one of its active metabolites, 3,4dihydrocilostazol, by 29% and 69% respectively .
* not marketed in Canada nexium Clopidogrel: Results from studies in healthy subjects have shown a pharmacokinetic/pharmacodynamic interaction between clopidogrel (300 mg loading dose/75mg daily maintenance dose) and esomeprazole (40 mg once daily) resulting in decreased exposure to the active metabolite of clopidogrel by an average of 40%, and resulting in decreased maximum inhibition of (ADP induced) platelet aggregation by an average of 14% .
It is, however, uncertain to what is nexium safe to take nexium drug test nexium 40 mg dosage instructions nexium drug nexium ec extent this interaction is clinically important .
One prospective, randomized (but incomplete) study (in over 3 760 patients comparing placebo with omeprazole 20 mg in patients treated with clopidogrel and ASA) and non-randomized, post-hoc analyses of data from large, prospective, randomized clinical outcome studies nexium (in over 47 000 patients) did not show any evidence of an increased risk for adverse cardiovascular outcome when clopidogrel and PPIs, including esomeprazole, were given concomitantly .
Results from a number of observational studies are inconsistent with regard to increased risk what are nexium tablets used for nexium long term side effects main ingredient in nexium nexium for or no increased risk for CV thromboembolic events when clopidogrel is given together with a PPI .
When clopidogrel was given together with a fixed dose combination of esomeprazole 20 mg + ASA 81 mg compared to clopidogrel alone in nexium a study in healthy subjects there was a decreased exposure by almost 40% of the active metabolite of clopidogrel .

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