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013 mg/kg-d tegretol (human) Source of toxicity value: MDH, 2011 Point of Departure: 3 . 8 mg/kg bw-d based on an average 53 kg 12-yr old child (McDowell and National Center for Health Statistics tegretol overdose treatment tegretol withdrawal side effects tegretol 200 mg uses tegretol level too (U . ) Human Equivalent Dose Adjustment: Not applicable Total uncertainty factor: 300 UF allocation: 10 intraspecies variability, 3 database tegretol insufficiencies (neurobehavioral developmental and immunotoxicity endpoints have not been adequately evaluated in available studies), 10 for use of a LOAEL instead of a NOAEL . Reference other name for tegretol tegretol and platelet count tegretol withdrawal symptoms tegretol monitoring Dose / Concentration: 0 . 8 mg/kg-d [LOAEL based on human minimum therapeutic dose for children at 200 mg/day (100 mg – 2x/day)(Novartis 2011), tegretol for seizures normal tegretol level tegretol level too high tegretol what is it used for equivalent to 3 .
Critical effect(s): Critical effects reported in various human studies include hematological effects (porphyria, decreased white blood cell tegretol counts, eosinophilia, thrombocytopenia, aplastic anemia); liver effects (liver enzyme induction, increased serum liver enzymes, jaundice, hepatitis); immune reactions (hypersensitivity); nervous system effects (suicide ideation); kidney effects (antidiuresis or hyponatremia, elevated BUN); reproductive endocrine effects (male/female sex hormone disturbances); skeletal effects (elevated serum markers for bone resorption, decreased bone density in children, decreased vitamin D levels); and thyroid hormone disturbances .
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